Ontology highlight
ABSTRACT:
SUBMITTER: Kraut DA
PROVIDER: S-EPMC3199294 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Kraut Daniel A DA Matouschek Andreas A
ACS chemical biology 20110812 10
The ubiquitin-proteasome system controls the concentrations of hundreds of regulatory proteins and removes misfolded and damaged proteins in eukaryotic cells. The proteasome recognizes ubiquitinated proteins and then engages its substrates at unstructured initiation regions. After initiation, it proceeds along the polypeptide chain, unraveling folded domains sequentially and degrading the protein completely. In vivo the proteasome can, and likely often does, initiate degradation at internal site ...[more]