Ontology highlight
ABSTRACT:
SUBMITTER: Marcucci R
PROVIDER: S-EPMC3199391 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
The EMBO journal 20110816 20
ADAR2 catalyses the deamination of adenosine to inosine at the GluR2 Q/R site in the pre-mRNA encoding the critical subunit of AMPA receptors. Among ADAR2 substrates this is the vital one as editing at this position is indispensable for normal brain function. However, the regulation of ADAR2 post-translationally remains to be elucidated. We demonstrate that the phosphorylation-dependent prolyl-isomerase Pin1 interacts with ADAR2 and is a positive regulator required for the nuclear localization a ...[more]