Ontology highlight
ABSTRACT:
SUBMITTER: Pfeiffer M
PROVIDER: S-EPMC3199514 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Pfeiffer Matthew M Kayzer Ernst-Bernhard EB Yang Xianmei X Abramson Ellen E Kenaston M Alexander MA Lago Cory U CU Lo Herng-Hsiang HH Sedensky Margaret M MM Lunceford Adam A Clarke Catherine F CF Wu Sarah J SJ McLeod Chris C Finkel Toren T Morgan Philip G PG Mills Edward M EM
The Journal of biological chemistry 20110823 43
The novel uncoupling proteins (UCP2-5) are implicated in the mitochondrial control of oxidant production, insulin signaling, and aging. Attempts to understand their functions have been complicated by overlapping expression patterns in most organisms. Caenorhabditis elegans nematodes are unique because they express only one UCP ortholog, ceUCP4 (ucp4). Here, we performed detailed metabolic analyzes in genetically modified nematodes to define the function of the ceUCP4. The knock-out mutant ucp4 ( ...[more]