Ontology highlight
ABSTRACT:
SUBMITTER: Gusarov I
PROVIDER: S-EPMC5481799 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Gusarov Ivan I Pani Bibhusita B Gautier Laurent L Smolentseva Olga O Eremina Svetlana S Shamovsky Ilya I Katkova-Zhukotskaya Olga O Mironov Alexander A Nudler Evgeny E
Nature communications 20170619
A high-sugar diet has been associated with reduced lifespan in organisms ranging from worms to mammals. However, the mechanisms underlying the harmful effects of glucose are poorly understood. Here we establish a causative relationship between endogenous glucose storage in the form of glycogen, resistance to oxidative stress and organismal aging in Caenorhabditis elegans. We find that glycogen accumulated on high dietary glucose limits C. elegans longevity. Glucose released from glycogen and use ...[more]