Ontology highlight
ABSTRACT:
SUBMITTER: Pyati UJ
PROVIDER: S-EPMC3200231 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Pyati Ujwal J UJ Gjini Evisa E Carbonneau Seth S Lee Jeong-Soo JS Guo Feng F Jette Cicely A CA Kelsell David P DP Look A Thomas AT
Developmental cell 20110901 3
Endoplasmic reticulum (ER) stress triggers tissue-specific responses that culminate in either cellular adaptation or apoptosis, but the genetic networks distinguishing these responses are not well understood. Here we demonstrate that ER stress induced in the developing zebrafish causes rapid apoptosis in the brain, spinal cord, tail epidermis, lens, and epiphysis. Focusing on the tail epidermis, we uncover an apoptotic response that depends on Puma, but not on p53 or Chop. puma is transcriptiona ...[more]