Ontology highlight
ABSTRACT:
SUBMITTER: Porteiro B
PROVIDER: S-EPMC5424198 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Nature communications 20170508
p53 family members control several metabolic and cellular functions. The p53 ortholog p63 modulates cellular adaptations to stress and has a major role in cell maintenance and proliferation. Here we show that p63 regulates hepatic lipid metabolism. Mice with liver-specific p53 deletion develop steatosis and show increased levels of p63. Down-regulation of p63 attenuates liver steatosis in p53 knockout mice and in diet-induced obese mice, whereas the activation of p63 induces lipid accumulation. ...[more]