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2-(5,6-Dihydro-benzimidazo[1,2-c]quinazolin-6-yl)-6-eth-oxy-phenol.

ABSTRACT: In the title compound, C(22)H(19)N(3)O(2), the phenol ring forms dihedral angles of 88.93?(10) and 87.95?(12)° with the benzimidazole system and the quinazoline benzene ring, respectively. In the crystal, mol-ecules are linked via O-H?N hydrogen bonds into infinite chains along [100]. An intra-molecular N-H?O hydrogen bond generates an S(6) ring.

SUBMITTER: Eltayeb NE

PROVIDER: S-EPMC3200659 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature

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2-(5,6-Dihydro-benzimidazo[1,2-c]quinazolin-6-yl)-6-eth-oxy-phenol.

Eltayeb Naser Eltaher NE Teoh Siang Guan SG Lo Kong Mun KM

Acta crystallographica. Section E, Structure reports online 20110831 Pt 9

In the title compound, C(22)H(19)N(3)O(2), the phenol ring forms dihedral angles of 88.93 (10) and 87.95 (12)° with the benzimidazole system and the quinazoline benzene ring, respectively. In the crystal, mol-ecules are linked via O-H⋯N hydrogen bonds into infinite chains along [100]. An intra-molecular N-H⋯O hydrogen bond generates an S(6) ring. ...[more]

PMID: 22059057

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2-(5,6-Dihydro-benzimidazo[1,2-c]quinazolin-6-yl)-5-meth-oxy-phenol.

Project description:In the title quinazoline derivative, C(21)H(17)N(3)O(2), the benzimidazole unit makes dihedral angles of 8.29?(5) and 81.79?(5)° with the benzene rings of the quinazoline and meth-oxy-phenol units, respectively. The nitro-gen-containing six-membered ring adopts a half-chair conformation. In the crystal, the mol-ecules are linked through O-H?N hydrogen bonds into screw chains along the b axis; adjacent chains are further connected by N-H?O hydrogen bonds, thereby forming a two-dimensional network lying parallel to the bc plane. Weak C-H?? and ??? inter-actions with centroid-centroid distances of 3.5258?(8) and 3.7184?(7)?Å are present and N?O [2.6816?(15) and 3.0519?(15)?Å] short contacts also occur.

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2-(5,6-Dihydro-benzimidazo[1,2-c]quinazolin-6-yl)phenol.

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Crystal structure of 5-(5,6-di-hydro-benzo[4,5]imidazo[1,2-c]quinazolin-6-yl)-2-meth-oxy-phenol.

Project description:In the mol-ecule of the title compound, C21H17N3O2, the 5,6-di-hydro-benzimidazo[1,2-c]quinazoline moiety is disordered over two orientations about a pseudo-mirror plane, with a refined occupancy ratio of 0.863 (2):0.137 (2). The dihedral angles formed by the benzimidazole ring system and the benzene ring of the quinazoline group are 14.28 (5) and 4.7 (3)° for the major and minor disorder components, respectively. An intra-molecular O-H⋯O hydrogen bond is present. In the crystal, mol-ecules are linked by O-H⋯N hydrogen bonds, forming chains running parallel to [10-1].

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Project description:The title compound, C(24)H(24)N(2)O(4)·CH(3)CN, a disubstituted benzimidazole, crystallized as an acetonitrile monosolvate. The benzene ring of the 2-eth-oxy-6-methyl-phenol substiuent is approximately perpendicular to the nearly planar benzimidazole ring system [maximum deviation = 0.016?(1)?Å], making a dihedral angle of 84.27?(8)°. The benzene ring of the 2-eth-oxy-phenol substituent is inclined to the benzimidazole mean plane by 29.68?(8)°. The dihedral angle between the benzene rings is 80.36?(9)°. In the mol-ecule, there are strong O-H?N and O-H?O hydrogen bonds. In the crystal, mol-ecules are connected by bifurcated O-H?(O,O) hydrogen bonds, forming chains propagating along [010].

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2-(2-{[4-Oxo-3-(2-phenyl-eth-yl)-3,4-dihydro-quinazolin-2-yl]sulfan-yl}eth-yl)-2,3-dihydro-1H-isoindole-1,3-dione.

Project description:In the title compound, C(26)H(21)N(3)O(3)S, the quinazolinyl group is essentially planar [r.m.s. deviation for the 10 non-H atoms = 0.057?Å]. The isoindoline-1,3-dione group is linked by an SCH(2)CH(2) chain to the pyrimidinyl C atom that lies between the two N atoms. Also, the phenyl group is linked by a CH(2)CH(2) chain at the N atom adjacent to the carbonyl group. This results in a conformation with these substituents lying to either side of the central quinazolinyl unit, with the former being approximately parallel [dihedral angle = 4.93?(7)°], and the phenyl group being inclined [dihedral angle = 71.61?(9)°] to the central quinazolinyl fused-ring system. In the crystal, mol-ecules are consolidated into a three-dimensional architecture by C-H?O inter-actions, involving all three carbonyl-O atoms, and ?-? inter-actions occurring between the pyrimidinyl and isoindole-benzene rings [inter-centroid distance = 3.5330?(13)?Å].

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Project description:In the title compound, C(10)H(13)NO(2), synthesized by the reaction of 2-hy-droxy-3-eth-oxy-benzaldehyde with methyl-amine, there is an an intra-molecular O-H?N hydrogen bond involving the hy-droxy substituent and the amino N atom. In the crystal, mol-ecules form inversion dimers connected by pairs of C-H?O hydrogen bonds.

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4-[(E)-(4-Eth-oxy-phen-yl)imino-meth-yl]phenol.

Project description:In the title compound, C(15)H(15)NO(2), the dihedral angle between the benzene rings is 52.04?(5)° and the mol-ecule has an E conformation about the central C=N bond. In the crystal, mol-ecules are connected by O-H?N hydrogen bonds, forming zigzag chains along the b axis. The crystal packing also features weak C-H?O inter-actions.

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