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2-[(4-Chloro-phenyl)-amino-meth-yl]phenol.

ABSTRACT: In the title mol-ecule, C(13)H(12)ClNO, the two benzene rings are twisted from each other by a dihedral angle of 68.60 (8)°. In the crystal structure, the hy-droxy and amino H atoms are involved in inter-molecular hydrogen bonds, O-H⋯N and N-H⋯O, respectively, resulting in R(4) (4)(8) loops about inversion centers.

SUBMITTER: Xu J

PROVIDER: S-EPMC3200954 | biostudies-literature |

REPOSITORIES: biostudies-literature

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2-[(Adamantan-1-yl)amino-meth-yl]-4-chloro-phenol hemihydrate.

Project description:In the title compound, C17H22ClNO·0.5H2O, the water mol-ecule O atom resides on a twofold rotation axis. In the organic mol-ecule, the phenol group forms an intra-molecular O-H?N hydrogen bond. In the crystal, pairs of organic mol-ecules are hydrogen bonded through bridging solvent water mol-ecules, forming chains along the b-axis direction.

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rac-4-Chloro-2-[({2-[(3-chloro-6-hy-droxy-2,4-dimethyl-benz-yl)(meth-yl)amino]-prop-yl}(meth-yl)amino)-meth-yl]-3,5-dimethyl-phenol.

Project description:The title compound, C(23)H(32)Cl(2)N(2)O(2), a potential chiral ligand for coordination chemistry, was prepared by a two-step reaction. The mol-ecule is located on a crystallographic centre of inversion. As a result, the methyl group bonded to the methyl-ene group is disordered over two equally occupied positions, sharing the same site as the H atom of the chiral C atom. As a further consequence of the crystallographic centrosymmetry, the 1,2-diamino-propane unit adopts an anti-periplanar conformation and the two benzene rings are coplanar. The central chain is in an all-trans arrangement. An intra-molecular O-H?N hydrogen bond makes an S(6) ring motif. A C-H?? inter-action links the mol-ecules into one-dimensional chains along the [001] direction.

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2-{(E)-[4-(Di-phenyl-amino)-phen-yl]imino-meth-yl}phenol.

Project description:The asymmetric unit of the title Schiff base molecule, C25H20N2O, contains two independent mol-ecules. In each mol-ecule, the C=N bond is in an E conformation. The most significant difference between the two mol-ecules is seen for the dihedral angles between the meth-oxy-substituted benzene ring and the two phenyl rings, which are 85.5?(1) and 82.3?(1)° in the first mol-ecule, and 49.0?(1) and 40.4?(1)° in the second. This conformational difference is reflected in the central C=N-C C torsion angle, which is 28.7?(2)° in the first mol-ecule and -29.8?(3)° in the other. In each mol-ecule, there is an intra-molecular O-H?N hydrogen bond.

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2-Bromo-4-chloro-6-[(1-phenyl-ethyl)-imino-meth-yl]phenol.

Project description:The title compound, C(15)H(13)BrClNO, is a Schiff base derived from the condensation of equimolar quanti-ties of 3-bromo-5-chloro-salicylaldehyde and 1-phenyl-ethanamine. The structure displays a trans configuration with respect to the imine C=N double bond. The N atom is also involved in an intra-molecular O-H-N hydrogen bond, which stabilizes the configuration of the compound.

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4-Chloro-2-((1R)-1-{[(R)-(2-chloro-phen-yl)(cyclo-pent-yl)meth-yl]amino}eth-yl)phenol.

Project description:The title compound, C(20)H(23)Cl(2)NO, was prepared by condensation of (R)-1-(2-chloro-phen-yl)-1-cyclo-pentyl-methanamine with 1-(5-chloro-2-hydroxy-phen-yl)ethanone, resulting in the formation of a new chiral center. The structural analysis confirms the absolute configuration of the title compound and the formation of the (R,R) diastereoisomer. There is an intra-molecular O-H?N hydrogen bond which stabilizes the conformation of the mol-ecule. The mol-ecules are linked to each other through weak C-H?? inter-actions.

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Project description:The title Schiff base compound, C(27)H(19)ClN(4)O, features two intra-molecular O-H?N and N-H?N hydrogen bonds involving the hydr-oxy and amino groups to generate S(6) and S(5) ring motifs, respectively. In the crystal structure, weak inter-molecular N-H?O and C-H?N inter-actions, together with ?-? contacts [centroid-centroid distances = 3.6294?(11)-3.6881?(11)?Å], link neighboring mol-ecules.

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2-Bromo-4-chloro-6-{(E)-[4-(diethyl-amino)-phen-yl]imino-meth-yl}phenol.

Project description:In the title compound, C(17)H(18)BrClN(2)O, the dihedral angle between the aromatic rings is 3.0?(1)°. The methyl-ethanamine group assumes an extended conformation. An intra-molecular O-H?N hydrogen bond generates an S(6) ring motif. The crystal packing is stabilized by C-H?? and ?-? [centroid-centroid distances = 3.691?(1) and 3.632?(1)?Å] inter-actions.

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2-[(4-Chloro-anilino)meth-yl]phenol.

Project description:In the title compound, C(13)H(12)ClNO, the dihedral angle between the two benzene ring planes is 68.71?(8)°. In the crystal, mol-ecules are linked by pairs of O-H?N hydrogen bonds into inversion dimers, which are further linked by intermolecular N-H?O interactions into a chain running parallel to the a axis.

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4-Chloro-2-((1R)-1-{[(R)-(2-chlorophen-yl)(cyclo-pent-yl)meth-yl]amino}prop-yl)phenol.

Project description:In the title compound, C(21)H(25)Cl(2)NO, the dihedral angle between the two benzene rings is 33.18?(11)°. The five-membered ring adopts an envelope conformation. There is an intra-molecular O-H?N hydrogen bond. In the crystal, mol-ecules are linked by weak N-H?Cl hydrogen bonds, forming a helical chain along the c axis.

| S-EPMC2968043 | biostudies-literature

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