Ontology highlight
ABSTRACT:
SUBMITTER: Fu Y
PROVIDER: S-EPMC3201172 | biostudies-literature | 2011 May
REPOSITORIES: biostudies-literature
Fu Yineng Y Nagy Janice A JA Brown Lawrence F LF Shih Shou-Ching SC Johnson Pamela Y PY Chan Christina K CK Dvorak Harold F HF Wight Thomas N TN
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20110316 5
Malignant tumors and chronic inflammatory diseases induce angiogenesis by overexpressing vascular endothelial growth factor A (VEGF-A/VPF). VEGF-A-induced pathological angiogenesis can be mimicked in immunoincompetent mice with an adenoviral vector expressing VEGF-A(164) (Ad-VEGF-A(164)). The initial step is generation of greatly enlarged "mother" vessels (MV) from preexisting normal venules by a process involving degradation of their rigid basement membranes. Immunohistochemical and Western blo ...[more]