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Rac-(6S)-6-Hy-droxy-6-{2-[2-(propan-2-yl-idene)hydrazinyl-idene]prop-yl}indolo[2,1-b]quinazolin-12(6H)-one.

ABSTRACT: The chiral title compound, C(21)H(20)N(4)O(2), crystallizes as a racemic mixture. In the crystal, mol-ecules form centrosymmetric ?-overlapping dimers [inter-planar distance = 3.338?(6)?Å], which are further connected along the a axis forming centrosymmetric dimers via O-H?N hydrogen bonds. C-H?O inter-actions are also observed. The indolo[2,1-b]quinazoline group is somewhat bent, with a small dihedral angle of 6.3?(4)° between the plane of the quinazoline system and the plane of the benzene ring of the indole moiety. The C=N-N=C atoms of the azine group is oriented almost perpendicular [84.1?(2)°] to the mean plane of the quinazoline system.

SUBMITTER: Rodstein ME 

PROVIDER: S-EPMC3201358 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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rac-(6S)-6-Hy-droxy-6-{2-[2-(propan-2-yl-idene)hydrazinyl-idene]prop-yl}indolo[2,1-b]quinazolin-12(6H)-one.

Rodstein Matthew E ME   Steffen Paul D PD   Krivogorsky Bogdana B   Grundt Peter P  

Acta crystallographica. Section E, Structure reports online 20110930 Pt 10

The chiral title compound, C(21)H(20)N(4)O(2), crystallizes as a racemic mixture. In the crystal, mol-ecules form centrosymmetric π-overlapping dimers [inter-planar distance = 3.338 (6) Å], which are further connected along the a axis forming centrosymmetric dimers via O-H⋯N hydrogen bonds. C-H⋯O inter-actions are also observed. The indolo[2,1-b]quinazoline group is somewhat bent, with a small dihedral angle of 6.3 (4)° between the plane of the quinazoline system and the plane of the benzene rin  ...[more]

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