Ontology highlight
ABSTRACT:
SUBMITTER: Griffin EE
PROVIDER: S-EPMC3201807 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Griffin Erik E EE Odde David J DJ Seydoux Geraldine G
Cell 20110901 6
Protein concentration gradients encode spatial information across cells and tissues and often depend on spatially localized protein synthesis. Here, we report that a different mechanism underlies the MEX-5 gradient. MEX-5 is an RNA-binding protein that becomes distributed in a cytoplasmic gradient along the anterior-to-posterior axis of the one-cell C. elegans embryo. We demonstrate that the MEX-5 gradient is a direct consequence of an underlying gradient in MEX-5 diffusivity. The MEX-5 diffusio ...[more]