Ontology highlight
ABSTRACT:
SUBMITTER: Yaddanapudi K
PROVIDER: S-EPMC3201973 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Yaddanapudi Kavitha K De Miranda Joari J Hornig Mady M Lipkin W Ian WI
PloS one 20111025 10
Toll-like receptor 3 (TLR3) signaling has been implicated in neural stem/precursor cell (NPC) proliferation. However, the molecular mechanisms involved, and their relationship to classical TLR-mediated innate immune pathways, remain unknown. Here, we report investigation of the mechanics of TLR3 signaling in neurospheres comprised of epidermal growth factor (EGF)-responsive NPC isolated from murine embryonic cerebral cortex of C57BL/6 (WT) or TLR3 deficient (TLR3(-/-)) mice. Our data indicate th ...[more]