PET imaging for attention deficit preclinical drug testing in neurofibromatosis-1 mice.
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ABSTRACT:
SUBMITTER: Brown JA
PROVIDER: S-EPMC3202049 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
PET imaging for attention deficit preclinical drug testing in neurofibromatosis-1 mice.
Brown Jacquelyn A JA Xu Jinbin J Diggs-Andrews Kelly A KA Wozniak David F DF Mach Robert H RH Gutmann David H DH
Experimental neurology 20110922 2
Attention system abnormalities represent a significant barrier to scholastic achievement in children with neurofibromatosis-1 (NF1). Using a novel mouse model of NF1-associated attention deficit (ADD), we demonstrate a presynaptic defect in striatal dopaminergic homeostasis and leverage this finding to apply [(11)C]-raclopride positron-emission tomography (PET) in the intact animal. While methylphenidate and l-Deprenyl correct both striatal dopamine levels on PET imaging and defective attention ...[more]
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