Ontology highlight
ABSTRACT:
SUBMITTER: Hu G
PROVIDER: S-EPMC3202282 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Hu Gangqing G Schones Dustin E DE Cui Kairong K Ybarra River R Northrup Daniel D Tang Qingsong Q Gattinoni Luca L Restifo Nicholas P NP Huang Suming S Zhao Keji K
Genome research 20110727 10
Enhancers of transcription activate transcription via binding of sequence-specific transcription factors to their target sites in chromatin. In this report, we identify GATA1-bound distal sites genome-wide and find a global reorganization of the nucleosomes at these potential enhancers during differentiation of hematopoietic stem cells (HSCs) to erythrocytes. We show that the catalytic subunit BRG1 of BAF complexes localizes to these distal sites during differentiation and generates a longer nuc ...[more]