Ontology highlight
ABSTRACT:
SUBMITTER: Song L
PROVIDER: S-EPMC3202292 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Song Lingyun L Zhang Zhancheng Z Grasfeder Linda L LL Boyle Alan P AP Giresi Paul G PG Lee Bum-Kyu BK Sheffield Nathan C NC Gräf Stefan S Huss Mikael M Keefe Damian D Liu Zheng Z London Darin D McDaniell Ryan M RM Shibata Yoichiro Y Showers Kimberly A KA Simon Jeremy M JM Vales Teresa T Wang Tianyuan T Winter Deborah D Zhang Zhuzhu Z Clarke Neil D ND Birney Ewan E Iyer Vishwanath R VR Crawford Gregory E GE Lieb Jason D JD Furey Terrence S TS
Genome research 20110712 10
The human body contains thousands of unique cell types, each with specialized functions. Cell identity is governed in large part by gene transcription programs, which are determined by regulatory elements encoded in DNA. To identify regulatory elements active in seven cell lines representative of diverse human cell types, we used DNase-seq and FAIRE-seq (Formaldehyde Assisted Isolation of Regulatory Elements) to map "open chromatin." Over 870,000 DNaseI or FAIRE sites, which correspond tightly t ...[more]