Ontology highlight
ABSTRACT:
SUBMITTER: Astarita G
PROVIDER: S-EPMC3202527 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
PloS one 20111026 10
The molecular bases of Alzheimer's disease (AD) remain unclear. We used a lipidomic approach to identify lipid abnormalities in the brains of subjects with AD (N = 37) compared to age-matched controls (N = 17). The analyses revealed statistically detectable elevations in levels of non-esterified monounsaturated fatty acids (MUFAs) and mead acid (20:3n-9) in mid-frontal cortex, temporal cortex and hippocampus of AD patients. Further studies showed that brain mRNAs encoding for isoforms of the rat ...[more]