Ontology highlight
ABSTRACT:
SUBMITTER: Sysi-Aho M
PROVIDER: S-EPMC3203065 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Sysi-Aho Marko M Ermolov Andrey A Gopalacharyulu Peddinti V PV Tripathi Abhishek A Seppänen-Laakso Tuulikki T Maukonen Johanna J Mattila Ismo I Ruohonen Suvi T ST Vähätalo Laura L Yetukuri Laxman L Härkönen Taina T Lindfors Erno E Nikkilä Janne J Ilonen Jorma J Simell Olli O Saarela Maria M Knip Mikael M Kaski Samuel S Savontaus Eriika E Orešič Matej M
PLoS computational biology 20111027 10
Recent evidence from serum metabolomics indicates that specific metabolic disturbances precede β-cell autoimmunity in humans and can be used to identify those children who subsequently progress to type 1 diabetes. The mechanisms behind these disturbances are unknown. Here we show the specificity of the pre-autoimmune metabolic changes, as indicated by their conservation in a murine model of type 1 diabetes. We performed a study in non-obese prediabetic (NOD) mice which recapitulated the design o ...[more]