Ontology highlight
ABSTRACT:
SUBMITTER: Garner AL
PROVIDER: S-EPMC3203215 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Garner Amanda L AL Park Junguk J Zakhari Joseph S JS Lowery Colin A CA Struss Anjali Kumari AK Sawada Daisuke D Kaufmann Gunnar F GF Janda Kim D KD
Journal of the American Chemical Society 20110915 40
Multivalency is a common principle in the recognition of cellular receptors, and multivalent agonists and antagonists have played a major role in understanding mammalian cell receptor biology. The study of bacterial cell receptors using similar approaches, however, has lagged behind. Herein we describe our efforts toward the development of a dendrimer-based multivalent probe for studying AI-2 quorum-sensing receptors. From these studies, we have discovered a chemical probe specific for Lsr-type ...[more]