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A multivalent probe for AI-2 quorum-sensing receptors.


ABSTRACT: Multivalency is a common principle in the recognition of cellular receptors, and multivalent agonists and antagonists have played a major role in understanding mammalian cell receptor biology. The study of bacterial cell receptors using similar approaches, however, has lagged behind. Herein we describe our efforts toward the development of a dendrimer-based multivalent probe for studying AI-2 quorum-sensing receptors. From these studies, we have discovered a chemical probe specific for Lsr-type AI-2 quorum-sensing receptors with the potential for enabling the identification of new bacterial species that utilize AI-2 as a quorum-sensing signaling molecule.

SUBMITTER: Garner AL 

PROVIDER: S-EPMC3203215 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature

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A multivalent probe for AI-2 quorum-sensing receptors.

Garner Amanda L AL   Park Junguk J   Zakhari Joseph S JS   Lowery Colin A CA   Struss Anjali Kumari AK   Sawada Daisuke D   Kaufmann Gunnar F GF   Janda Kim D KD  

Journal of the American Chemical Society 20110915 40


Multivalency is a common principle in the recognition of cellular receptors, and multivalent agonists and antagonists have played a major role in understanding mammalian cell receptor biology. The study of bacterial cell receptors using similar approaches, however, has lagged behind. Herein we describe our efforts toward the development of a dendrimer-based multivalent probe for studying AI-2 quorum-sensing receptors. From these studies, we have discovered a chemical probe specific for Lsr-type  ...[more]

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