Claudins in renal physiology and disease.
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ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC3203223 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Publications
Claudins in renal physiology and disease.
Li Jiahua J Ananthapanyasut Wanwarat W Yu Alan S L AS
Pediatric nephrology (Berlin, Germany) 20110302 12
The tight junction forms the paracellular permeability barrier in all epithelia, including the renal tubule. Claudins are a family of tight junction membrane proteins with four transmembrane domains that form the paracellular pore and barrier. Their first extracellular domain appears to be important for determining selectivity. A number of claudin isoforms have been found to be important in renal tubule function, both in adults and in neonates. Familial hypomagnesemic hypercalciuria with nephroc ...[more]
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