Ontology highlight
ABSTRACT:
SUBMITTER: Fujimoto H
PROVIDER: S-EPMC3204191 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Fujimoto Hirokazu H Hirase Tetsuaki T Miyazaki Yoshiyuki Y Hara Hiromitsu H Ide-Iwata Noriko N Nishimoto-Hazuku Ai A Saris Christiaan J M CJ Yoshida Hiroki H Node Koichi K
The American journal of pathology 20110915 5
Inflammation driven by immune cells and pro-inflammatory cytokines is implicated in pancreatic β-cell injury, leading to the development of diabetes mellitus. IL-27, a cytokine consisting of IL-27p28 and Epstein-Barr virus-induced gene 3 (EBI3), binds a membrane-bound heterodimeric receptor consisting of the IL-27 receptor α chain (WSX-1) and gp130. IL-27 has anti-inflammatory properties that regulate T-cell polarization and cytokine production. We evaluated blood glucose and islet proinsulin co ...[more]