Genetics and pathogenesis of inflammatory bowel disease.
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ABSTRACT:
SUBMITTER: Khor B
PROVIDER: S-EPMC3204665 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Genetics and pathogenesis of inflammatory bowel disease.
Khor Bernard B Gardet Agnès A Xavier Ramnik J RJ
Nature 20110615 7351
Recent advances have provided substantial insight into the maintenance of mucosal immunity and the pathogenesis of inflammatory bowel disease. Cellular programs responsible for intestinal homeostasis use diverse intracellular and intercellular networks to promote immune tolerance, inflammation or epithelial restitution. Complex interfaces integrate local host and microbial signals to activate appropriate effector programs selectively and even drive plasticity between these programs. In addition, ...[more]
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