Pathway paradigms revealed from the genetics of inflammatory bowel disease.
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ABSTRACT:
SUBMITTER: Graham DB
PROVIDER: S-EPMC7871366 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Pathway paradigms revealed from the genetics of inflammatory bowel disease.
Graham Daniel B DB Xavier Ramnik J RJ
Nature 20200226 7796
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and amplified by the confluence of multiple genetic and environmental variables that perturb the immune-microbiome axis. The challenge of dissecting pathological mechanisms underlying IBD has led to the development of transformative approaches in human genetics and functional genomics. Here we describe IBD as a model disease in the context of leveraging human genetics to dissect interactions in cellular and molecula ...[more]
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