Ontology highlight
ABSTRACT:
SUBMITTER: Kojima K
PROVIDER: S-EPMC3204912 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Kojima Kensuke K McQueen Teresa T Chen Ye Y Jacamo Rodrigo R Konopleva Marina M Shinojima Naoki N Shpall Elizabeth E Huang Xuelin X Andreeff Michael M
Blood 20110825 16
Fms-like tyrosine kinase-3 (FLT3) inhibitors have been used to overcome the dismal prognosis of acute myeloid leukemia (AML) with FLT3 mutations. Clinical results with FLT3 inhibitor monotherapy have shown that bone marrow responses are commonly less pronounced than peripheral blood responses. We investigated the role of p53 in bone marrow stromal cells in stromal cell-mediated resistance to FLT3 inhibition in FLT3 mutant AML. While the FLT3 inhibitor FI-700 induced apoptosis in FLT3 mutant AML ...[more]