Ontology highlight
ABSTRACT:
SUBMITTER: Lin J
PROVIDER: S-EPMC3204995 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Lin Jiang J Yao Dong-ming DM Qian Jun J Chen Qin Q Qian Wei W Li Yun Y Yang Jing J Wang Cui-zhu CZ Chai Hai-yan HY Qian Zhen Z Xiao Gao-fei GF Xu Wen-rong WR
PloS one 20111031 10
Somatic mutations of DNMT3A gene have recently been reported in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We examined the entire coding sequences of DNMT3A gene by high-resolution melting analysis and sequencing in Chinese patients with myeloid malignancies. R882 mutations were found in 12/182 AML and in 4/51 MDS, but not in either 79 chronic myeloid leukemia (CML), or 57 myeloproliferative neoplasms (MPNs), or 4 chronic monomyelocytic leukemia. No other DNMT3A mutations w ...[more]