Ontology highlight
ABSTRACT:
SUBMITTER: Qian J
PROVIDER: S-EPMC3446943 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Qian Jun J Yao Dong-ming DM Lin Jiang J Qian Wei W Wang Cui-zhu CZ Chai Hai-yan HY Yang Jing J Li Yun Y Deng Zhao-qun ZQ Ma Ji-chun JC Chen Xing-xing XX
PloS one 20120919 9
Somatic mutations of U2AF1 gene have recently been identified in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). In this study, we analyzed the frequency and clinical impact of U2AF1 mutations in a cohort of 452 Chinese patients with myeloid neoplasms. Mutations in U2AF1 were found in 2.5% (7/275) of AML and 6.3% (6/96) of MDS patients, but in none of 81 CML. All mutations were heterozygous missense mutations affecting codon S34 or Q157. There was no significant association of U ...[more]