Ontology highlight
ABSTRACT:
SUBMITTER: Martin MM
PROVIDER: S-EPMC3205567 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Martin Melvenia M MM Ryan Michael M Kim RyangGuk R Zakas Anna L AL Fu Haiqing H Lin Chii Mei CM Reinhold William C WC Davis Sean R SR Bilke Sven S Liu Hongfang H Doroshow James H JH Reimers Mark A MA Valenzuela Manuel S MS Pommier Yves Y Meltzer Paul S PS Aladjem Mirit I MI
Genome research 20110803 11
This report investigates the mechanisms by which mammalian cells coordinate DNA replication with transcription and chromatin assembly. In yeast, DNA replication initiates within nucleosome-free regions, but studies in mammalian cells have not revealed a similar relationship. Here, we have used genome-wide massively parallel sequencing to map replication initiation events, thereby creating a database of all replication initiation sites within nonrepetitive DNA in two human cell lines. Mining this ...[more]