Ontology highlight
ABSTRACT:
SUBMITTER: Berger I
PROVIDER: S-EPMC3206062 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Berger Ilana I Guttman Chen C Amar Dotan D Zarivach Raz R Aharoni Amir A
PloS one 20111101 11
Cytosolic sulfotransferases (SULTs) are mammalian enzymes that detoxify a wide variety of chemicals through the addition of a sulfate group. Despite extensive research, the molecular basis for the broad specificity of SULTs is still not understood. Here, structural, protein engineering and kinetic approaches were employed to obtain deep understanding of the molecular basis for the broad specificity, catalytic activity and substrate inhibition of SULT1A1. We have determined five new structures of ...[more]