A continuum model for tumour suppression.
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ABSTRACT:
SUBMITTER: Berger AH
PROVIDER: S-EPMC3206311 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Publications
A continuum model for tumour suppression.
Berger Alice H AH Knudson Alfred G AG Pandolfi Pier Paolo PP
Nature 20110810 7359
This year, 2011, marks the forty-year anniversary of the statistical analysis of retinoblastoma that provided the first evidence that tumorigenesis can be initiated by as few as two mutations. This work provided the foundation for the two-hit hypothesis that explained the role of recessive tumour suppressor genes (TSGs) in dominantly inherited cancer susceptibility syndromes. However, four decades later, it is now known that even partial inactivation of tumour suppressors can critically contribu ...[more]
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