Unknown

Dataset Information

0

Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin.

ABSTRACT: A series of six novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes was synthesized and characterized in detail by elemental analysis, FT-IR, ESI-MS, HPLC, multinuclear ((1)H, (13)C, (15)N, (195)Pt) NMR spectroscopy and in one case by X-ray diffraction. Cytotoxic properties of the complexes were evaluated in four human tumor cell lines originating from ovarian carcinoma (CH1 and SK-OV-3), colon carcinoma (SW480) and non-small cell lung cancer (A549) by means of the MTT colorimetrical assay. In addition, their octanol/water partition coefficients (log P values) were determined. Remarkably the most active (and also most lipophilic) compounds, having 4-propyloxy-4-oxobutanoato and 4-(2-propyloxy)-4-oxobutanoato axial ligands, showed IC(50) values down to the low nanomolar range.

SUBMITTER: Varbanov H 

PROVIDER: S-EPMC3206992 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Synthesis and characterization of novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes with higher cytotoxicity than cisplatin.

Varbanov Hristo H   Valiahdi Seied M SM   Legin Anton A AA   Jakupec Michael A MA   Roller Alexander A   Galanski Mathea S. MS   Keppler Bernhard K BK  

European journal of medicinal chemistry 20110908 11

A series of six novel bis(carboxylato)dichloridobis(ethylamine)platinum(IV) complexes was synthesized and characterized in detail by elemental analysis, FT-IR, ESI-MS, HPLC, multinuclear ((1)H, (13)C, (15)N, (195)Pt) NMR spectroscopy and in one case by X-ray diffraction. Cytotoxic properties of the complexes were evaluated in four human tumor cell lines originating from ovarian carcinoma (CH1 and SK-OV-3), colon carcinoma (SW480) and non-small cell lung cancer (A549) by means of the MTT colorime  ...[more]

Similar Datasets

Unknown Synthesis, characterization, and cytotoxicity of platinum(IV) carbamate complexes.
| S-EPMC3065953 | biostudies-literature
Unknown Engineering Novel Amphiphilic Platinum(IV) Complexes to Co-Deliver Cisplatin and Doxorubicin.
| S-EPMC11397443 | biostudies-literature
Unknown Dichloridobis(pyridine-2-carboxyl-ato-κN,O)platinum(IV) acetonitrile solvate.
| S-EPMC2969797 | biostudies-literature
Unknown Behavior of platinum(iv) complexes in models of tumor hypoxia: cytotoxicity, compound distribution and accumulation.
| S-EPMC6130773 | biostudies-literature
Unknown Bioactive Platinum(IV) Complexes Incorporating Halogenated Phenylacetates.
| S-EPMC9611758 | biostudies-literature
Unknown EGFR-targeting peptide-coupled platinum(IV) complexes.
| S-EPMC5443859 | biostudies-literature
Unknown Acetate-bridged platinum(III) complexes derived from cisplatin.
| S-EPMC3457664 | biostudies-literature
Unknown Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes-A More Selective Anticancer Treatment?
| S-EPMC10221222 | biostudies-literature
Unknown Axial functionalisation of photoactive diazido platinum(iv) anticancer complexes.
| S-EPMC7610473 | biostudies-literature
Unknown Insertion of (Bioactive) Equatorial Ligands into Platinum(IV) Complexes.
| S-EPMC10952260 | biostudies-literature