Ontology highlight
ABSTRACT:
SUBMITTER: Schreiber-Brynzak E
PROVIDER: S-EPMC6130773 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Schreiber-Brynzak Ekaterina E Pichler Verena V Heffeter Petra P Hanson Buck B Theiner Sarah S Lichtscheidl-Schultz Irene I Kornauth Christoph C Bamonti Luca L Dhery Vineet V Groza Diana D Berry David D Berger Walter W Galanski Markus M Jakupec Michael A MA Keppler Bernhard K BK
Metallomics : integrated biometal science 20160210 4
Hypoxia in solid tumors remains a challenge for conventional cancer therapeutics. As a source for resistance, metastasis development and drug bioprocessing, it influences treatment results and disease outcome. Bioreductive platinum(iv) prodrugs might be advantageous over conventional metal-based therapeutics, as biotransformation in a reductive milieu, such as under hypoxia, is required for drug activation. This study deals with a two-step screening of experimental platinum(iv) prodrugs with dif ...[more]