Ontology highlight
ABSTRACT:
SUBMITTER: Stenzel D
PROVIDER: S-EPMC3207109 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Stenzel Denise D Franco Claudio A CA Estrach Soline S Mettouchi Amel A Sauvaget Dominique D Rosewell Ian I Schertel Andreas A Armer Hannah H Domogatskaya Anna A Rodin Sergey S Tryggvason Karl K Collinson Lucy L Sorokin Lydia L Gerhardt Holger H Gerhardt Holger H
EMBO reports 20111028 11
How individual components of the vascular basement membrane influence endothelial cell behaviour remains unclear. Here we show that laminin α4 (Lama4) regulates tip cell numbers and vascular density by inducing endothelial Dll4/Notch signalling in vivo. Lama4 deficiency leads to reduced Dll4 expression, excessive filopodia and tip cell formation in the mouse retina, phenocopying the effects of Dll4/Notch inhibition. Lama4-mediated Dll4 expression requires a combination of integrins in vitro and ...[more]