Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC6338428 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Wang Shue S Sun Jian J Xiao Yuan Y Lu Yi Y Zhang Donna D DD Wong Pak Kin PK
Advanced biosystems 20170131 1-2
Mechanical force plays pivotal roles in vascular development during tissue growth and regeneration. Nevertheless, the process by which mechanical force controls the vascular architecture remains poorly understood. Using a systems bioengineering approach, we show that intercellular tension negatively regulates tip cell formation via Notch1-Dll4 signaling in mouse retinal angiogenesis in vivo, sprouting embryoid bodies, and human endothelial cell networks <i>in vitro</i>. Reducing the intercellula ...[more]