Ontology highlight
ABSTRACT:
SUBMITTER: Tonges L
PROVIDER: S-EPMC3207219 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Tönges Lars L Koch Jan-Christoph JC Bähr Mathias M Lingor Paul P
Frontiers in molecular neuroscience 20111103
Regenerative failure in the CNS largely depends on pronounced growth inhibitory signaling and reduced cellular survival after a lesion stimulus. One key mediator of growth inhibitory signaling is Rho-associated kinase (ROCK), which has been shown to modulate growth cone stability by regulation of actin dynamics. Recently, there is accumulating evidence the ROCK also plays a deleterious role for cellular survival. In this manuscript we illustrate that ROCK is involved in a variety of intracellula ...[more]