Ontology highlight
ABSTRACT:
SUBMITTER: Zhuang C
PROVIDER: S-EPMC3207404 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Zhuang Chunmei C Tang Hongxing H Dissanaike Sharmila S Cobos Everardo E Tao Yunxia Y Dai Zonghan Z
The Journal of biological chemistry 20110907 44
Coordinated actin remodeling is crucial for cell entry into mitosis. The WAVE regulatory complex is a key regulator of actin assembly, yet how the WAVE signaling is regulated to coordinate actin assembly with mitotic entry is not clear. Here, we have uncovered a novel mechanism that regulates the WAVE complex at the onset of mitosis. We found that the Bcr-Abl-stimulated F-actin assembly is abrogated during mitosis. This mitotic inhibition of F-actin assembly is accompanied by an attenuation of B ...[more]