Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi T
PROVIDER: S-EPMC2171270 | biostudies-literature | 2005 Nov
REPOSITORIES: biostudies-literature
Yamaguchi Tomoya T Goto Hidemasa H Yokoyama Tomoya T Silljé Herman H Hanisch Anja A Uldschmid Andreas A Takai Yasushi Y Oguri Takashi T Nigg Erich A EA Inagaki Masaki M
The Journal of cell biology 20051031 3
Several kinases phosphorylate vimentin, the most common intermediate filament protein, in mitosis. Aurora-B and Rho-kinase regulate vimentin filament separation through the cleavage furrow-specific vimentin phosphorylation. Cdk1 also phosphorylates vimentin from prometaphase to metaphase, but its significance has remained unknown. Here we demonstrated a direct interaction between Plk1 and vimentin-Ser55 phosphorylated by Cdk1, an event that led to Plk1 activation and further vimentin phosphoryla ...[more]