Ontology highlight
ABSTRACT:
SUBMITTER: Cvetkov TL
PROVIDER: S-EPMC3207480 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Cvetkov Teresa L TL Huynh Kevin W KW Huynh Kevin W KW Cohen Matthew R MR Moiseenkova-Bell Vera Y VY
The Journal of biological chemistry 20110909 44
Transient receptor potential ankyrin 1 (TRPA1) is a non-selective ion channel, which is expressed in nociceptor sensory neurons and transduces chemical, inflammatory, and neuropathic pain signals. Numerous non-reactive compounds and electrophilic compounds, such as endogenous inflammatory mediators and exogenous pungent chemicals, can activate TRPA1. Here we report a 16-Å resolution structure of purified, functional, amphipol-stabilized TRPA1 analyzed by single-particle EM. Molecular models of t ...[more]