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Association of genetic loci with blood lipids in the Chinese population.

ABSTRACT: Recent genome-wide association (GWA) studies have identified a number of novel genetic determinants of blood lipid concentrations in Europeans. However, it is still unclear whether these loci identified in the Caucasian GWA studies also exert the same effect on lipid concentrations in the Chinese population.We conducted a replication study assessing associations between SNPs at 15 loci and blood lipid and lipoprotein concentrations in two Chinese cohorts, comprising 2533 and 2105 individuals respectively. SNPs in APO(A1/C3/A4/A5), TIMD4-HAVCR1, DOCK7, TRIB1, ABCA1, and TOMM40-APOE showed strong associations with at least one lipids trait, and rs174546 in FADS1/2/3 showed modest association with triglyceride in the Chinese population.We successfully replicated 7 loci associated plasma lipid concentrations in the Chinese population. Our study confirmed the implication of APO(A1/C3/A4/A5), TOMM40-APOE, ABCA1, DOCK7, TIMD4-HAVCR1, TRIB1 and FADS1/2 in plasma lipid and lipoprotein concentrations in Chinese population.

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC3207848 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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Association of genetic loci with blood lipids in the Chinese population.

Zhang Zhou Z   Tao Liming L   Chen Zhuo Z   Zhou Daizhan D   Kan Mengyuan M   Zhang Di D   Li Can C   He Lin L   Liu Yun Y  

PloS one 20111103 11

<h4>Background</h4>Recent genome-wide association (GWA) studies have identified a number of novel genetic determinants of blood lipid concentrations in Europeans. However, it is still unclear whether these loci identified in the Caucasian GWA studies also exert the same effect on lipid concentrations in the Chinese population.<h4>Methods and results</h4>We conducted a replication study assessing associations between SNPs at 15 loci and blood lipid and lipoprotein concentrations in two Chinese co  ...[more]

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