Ontology highlight
ABSTRACT:
SUBMITTER: Bhansali P
PROVIDER: S-EPMC3208063 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20111010 21
The histone deacetylase inhibitor largazole 1 was synthesized by a convergent approach that involved several efficient and high yielding single pot multistep protocols. Initial attempts using tert-butyl as thiol protecting group proved problematic, and synthesis was accomplished by switching to the trityl protecting group. This synthetic protocol provides a convenient approach to many new largazole analogues. Three side chain analogues with multiple heteroatoms for chelation with Zn(2+) were syn ...[more]