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MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: a Children's Oncology Group (COG) study.

ABSTRACT: BACKGROUND:Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements. PROCEDURE:Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age. RESULTS:Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significantly higher age at diagnosis for infants with t(9;11) translocations compared to all other translocation partners in both acute lymphoblastic leukemia and acute myeloid leukemia cases. CONCLUSION:These patterns may provide important etiological insight into the biology of infant leukemia.

SUBMITTER: Sam TN

PROVIDER: S-EPMC3208122 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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MLL gene rearrangements in infant leukemia vary with age at diagnosis and selected demographic factors: a Children's Oncology Group (COG) study.

Sam Thien N TN Kersey John H JH Linabery Amy M AM Johnson Kimberly J KJ Heerema Nyla A NA Hilden Joanne M JM Davies Stella M SM Reaman Gregory H GH Ross Julie A JA

Pediatric blood & cancer 20110728 6

<h4>Background</h4>Infant leukemias have a high frequency of mixed lineage leukemia (MLL) gene rearrangements.<h4>Procedure</h4>Using data from a large etiologic study, we evaluated the distribution of selected demographic factors among 374 infant leukemia cases by leukemic subtype, MLL status and diagnosis age.<h4>Results</h4>Overall, 228 cases were MLL+. Compared to white infants, black infants were significantly less likely to have MLL+ leukemia. Further, there was a statistically significant ...[more]

PMID: 21800415

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