Ontology highlight
ABSTRACT:
SUBMITTER: Osada T
PROVIDER: S-EPMC3208159 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Osada Takashi T Gu Yu-Huan YH Kanazawa Masato M Tsubota Yoshiaki Y Hawkins Brian T BT Spatz Maria M Milner Richard R del Zoppo Gregory J GJ
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110720 10
The hypothesis tested by these studies states that in addition to interendothelial cell tight junction proteins, matrix adhesion by β(1)-integrin receptors expressed by endothelial cells have an important role in maintaining the cerebral microvessel permeability barrier. Primary brain endothelial cells from C57 BL/6 mice were incubated with β(1)-integrin function-blocking antibody (Ha2/5) or isotype control and the impacts on claudin-5 expression and microvessel permeability were quantified. Bot ...[more]