Ontology highlight
ABSTRACT:
SUBMITTER: Sorensen EW
PROVIDER: S-EPMC5931132 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Sorensen Elizabeth W EW Lian Jeffrey J Ozga Aleksandra J AJ Miyabe Yoshishige Y Ji Sophina W SW Bromley Shannon K SK Mempel Thorsten R TR Luster Andrew D AD
JCI insight 20180419 8
Malaria remains one of the world's most significant human infectious diseases and cerebral malaria (CM) is its most deadly complication. CM pathogenesis remains incompletely understood, hindering the development of therapeutics to prevent this lethal complication. Elevated levels of the chemokine CXCL10 are a biomarker for CM, and CXCL10 and its receptor CXCR3 are required for experimental CM (ECM) in mice, but their role has remained unclear. Using multiphoton intravital microscopy, CXCR3 recep ...[more]