Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez-Ruiz Y
PROVIDER: S-EPMC3208563 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Sanchez-Ruiz Yovan Y Valitutti Salvatore S Dupre Loic L
PloS one 20111104 11
During differentiation, cytotoxic T lymphocytes (CTL) acquire their killing potential through the biogenesis and maturation of lytic granules that are secreted upon target cell recognition. How lytic granule load in lytic molecules evolves during CTL differentiation and which subsets of lytic granules are secreted following activation remains to be investigated. We set up a flow cytometry approach to analyze single lytic granules isolated from primary human CTL according to their size and molecu ...[more]