Ontology highlight
ABSTRACT:
SUBMITTER: Nunez-Andrade N
PROVIDER: S-EPMC5023047 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Núñez-Andrade Norman N Iborra Salvador S Trullo Antonio A Moreno-Gonzalo Olga O Calvo Enrique E Catalán Elena E Menasche Gaël G Sancho David D Vázquez Jesús J Yao Tso-Pang TP Martín-Cófreces Noa Beatriz NB Sánchez-Madrid Francisco F
Journal of cell science 20160211 7
HDAC6 is a tubulin deacetylase involved in many cellular functions related to cytoskeleton dynamics, including cell migration and autophagy. In addition, HDAC6 affects antigen-dependent CD4(+)T cell activation. In this study, we show that HDAC6 contributes to the cytotoxic function of CD8(+)T cells. Immunization studies revealed defective cytotoxic activity in vivo in the absence of HDAC6. Adoptive transfer of wild-type or Hdac6(-/-)CD8(+)T cells to Rag1(-/-)mice demonstrated specific impairment ...[more]