Dataset Information

DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze.

ABSTRACT: BACKGROUND: DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically involved in spine formation, the involvement of DIP/WISH in these processes is unknown. RESULTS: We found that DIP/WISH-deficient hippocampal CA1 neurons exhibit enhanced long-term potentiation via modulation of both pre- and post-synaptic events. Consistent with these electrophysiological findings, DIP/WISH-deficient mice, particularly at a relatively young age, found the escape hole more rapidly in the Barnes maze test. CONCLUSIONS: We conclude that DIP/WISH deletion improves performance in the Barnes maze test in mice probably through increased hippocampal long-term potentiation.

SUBMITTER: Asrar S

PROVIDER: S-EPMC3208581 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature

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DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze.

Asrar Suhail S Kaneko Keiko K Takao Keizo K Negandhi Jaina J Matsui Makoto M Shibasaki Koji K Miyakawa Tsuyoshi T Harrison Robert V RV Jia Zhengping Z Salter Michael W MW Tominaga Makoto M Fukumi-Tominaga Tomoko T

Molecular brain 20111021

<h4>Background</h4>DIP (diaphanous interacting protein)/WISH (WASP interacting SH3 protein) is a protein involved in cytoskeletal signaling which regulates actin cytoskeleton dynamics and/or microtubules mainly through the activity of Rho-related proteins. Although it is well established that: 1) spine-head volumes change dynamically and reflect the strength of the synapse accompanying long-term functional plasticity of glutamatergic synaptic transmission and 2) actin organization is critically ...[more]

PMID: 22018352

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Dataset Information

DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze.

Publications

DIP/WISH deficiency enhances synaptic function and performance in the Barnes maze.

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