DNA repair gene polymorphisms and risk of chronic atrophic gastritis: a case-control study.

ABSTRACT:

Background

Recent studies have reported associations of DNA repair pathway gene variants and risk of various cancers and precancerous lesions, such as chronic atrophic gastritis (CAG).

Methods

A nested case-control study within the German population-based ESTHER cohort was conducted, including 533 CAG cases and 1054 controls. Polymorphisms in eleven DNA repair genes (APEX1, ERCC1, ERCC2/XPD, PARP1 and XRCC1), in CD3EAP/ASE-1 and PPP1R13L were analysed.

Results

No association was disclosed for any of the analysed polymorphisms. Nor did stratified analyses according to ages < 65 and ≥ 65 years show any significant association with CAG risk.

Conclusions

The results of this large German case-control study do not reveal associations of DNA repair pathway polymorphis

SUBMITTER: Frank B 

PROVIDER: S-EPMC3209461 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature