Ontology highlight
ABSTRACT:
SUBMITTER: Strasfeld DB
PROVIDER: S-EPMC3209517 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Strasfeld David B DB Ling Yun L YL Shim Sang-Hee SH Zanni Martin T MT
Journal of the American Chemical Society 20080507 21
Amyloid forming proteins have been implicated in many human diseases. The kinetics of amyloid fiber formation are of particular interest because evidence points to intermediate folding structures as potential cytotoxic species. The standard methods for monitoring the kinetics are to use fluorescence or circular dichroism spectroscopy, which do not uniquely resolve secondary structures. In this work, we use a new technology for rapidly scanning 2D-IR spectra that allows us to follow the fiber for ...[more]