Ontology highlight
ABSTRACT:
SUBMITTER: Ribeiro D
PROVIDER: S-EPMC5651775 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Ribeiro Diana D Horvath Istvan I Heath Nikki N Hicks Ryan R Forslöw Anna A Wittung-Stafshede Pernilla P
Proceedings of the National Academy of Sciences of the United States of America 20171002 42
Extracellular vesicles (EVs) are small vesicles released by cells to aid cell-cell communication and tissue homeostasis. Human islet amyloid polypeptide (IAPP) is the major component of amyloid deposits found in pancreatic islets of patients with type 2 diabetes (T2D). IAPP is secreted in conjunction with insulin from pancreatic β cells to regulate glucose metabolism. Here, using a combination of analytical and biophysical methods in vitro, we tested whether EVs isolated from pancreatic islets o ...[more]