Ontology highlight
ABSTRACT:
SUBMITTER: Levantini E
PROVIDER: S-EPMC3209778 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Levantini Elena E Lee Sanghoon S Radomska Hanna S HS Hetherington Christopher J CJ Alberich-Jorda Meritxell M Amabile Giovanni G Zhang Pu P Gonzalez David A DA Zhang Junyan J Basseres Daniela S DS Wilson Nicola K NK Koschmieder Steffen S Huang Gang G Zhang Dong-Er DE Ebralidze Alexander K AK Bonifer Constanze C Okuno Yutaka Y Gottgens Bertie B Tenen Daniel G DG
The EMBO journal 20110826 19
The transcription factor RUNX1 is essential to establish the haematopoietic gene expression programme; however, the mechanism of how it activates transcription of haematopoietic stem cell (HSC) genes is still elusive. Here, we obtained novel insights into RUNX1 function by studying regulation of the human CD34 gene, which is expressed in HSCs. Using transgenic mice carrying human CD34 PAC constructs, we identified a novel downstream regulatory element (DRE), which is bound by RUNX1 and is necess ...[more]