Ontology highlight
ABSTRACT:
SUBMITTER: Miftakhova R
PROVIDER: S-EPMC4614519 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Miftakhova Regina R Hedblom Andreas A Batkiewicz Leah L Anagnosaki Lola L Zhang Yuan Y Sjölander Anita A Wingren Anette Gjörloff AG Wolgemuth Debra J DJ Persson Jenny L JL Persson Jenny L JL
Cell cycle (Georgetown, Tex.) 20150101 12
It remains poorly understood how the haematopoietic stem/progenitor cells (HSPC) are attracted to their niches and the functional consequences of such interaction. In the present study, we show that the cell cycle regulator cyclin A1 in association with vascular endothelial growth factor receptor 1 (VEGFR1), is required for HSPC and their niches to maintain their function and proper interaction. In the absence of cyclin A1, the HSPC in the BM are increased in their frequency and display an incre ...[more]