Ontology highlight
ABSTRACT:
SUBMITTER: Quintana A
PROVIDER: S-EPMC3209779 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
The EMBO journal 20110816 19
Cell polarization enables restriction of signalling into microdomains. Polarization of lymphocytes following formation of a mature immunological synapse (IS) is essential for calcium-dependent T-cell activation. Here, we analyse calcium microdomains at the IS with total internal reflection fluorescence microscopy. We find that the subplasmalemmal calcium signal following IS formation is sufficiently low to prevent calcium-dependent inactivation of ORAI channels. This is achieved by localizing mi ...[more]